New Treatment Approaches of Pseudomonas aeruginosa Infection in Cystic Fibrosis Lung Disease
نویسندگان
چکیده
Implication for health policy/practice/research/medical education: Some new treatment strategies may improve the health of Cystic Fibrosis patients. Novel pharmaceutical formulations such as microspheres would also be an interesting approach in this area. Copyright © 2013, Iranian Society of Pediatrics; Licensee Safnek Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Dear Editor,
منابع مشابه
Genetic Profiling of Pseudomonas aeruginosa Isolates from Iranian Patients with Cystic Fibrosis Using RAPD-PCR and PFGE
Objective(s) Pseudomonas aeruginosa is the most important cause of chronic lung infections and death in patients with cystic fibrosis. Determining the distribution of specific strains within patient populations is important in order to examine the epidemiology of the disease and the possibility of cross infection among patients. Materials and Methods Forty six Iranian patients with cystic fib...
متن کاملA Review of The Role of The Microbiome on Immune Responses and Its Association With Cystic Fibrosis
In recent years, the microbiome has been recognized as a key regulator of immune responses. Evidence suggests that changes in the microbiome can lead to chronic disease and even exacerbation of the disease. Impairment of innate immunity resulting from microbial incompatibility may worsen host susceptibility to infection and exacerbate chronic lung diseases. Specific microbes play a key role in ...
متن کاملSymmetry of Frequency information in Right and Left Lung sound and Infection Detection in Cystic Fibrosis Patients
Cystic fibrosis (CF) is the most common autosomal recessive disorder in white skinned individuals. Chronic lung infection is the main cause of mortality in this disease. Approximately 60–75 % of adult CF patients frequently suffer from Pseudomonas aeruginosa (PA) infection that is strongly associated with inflammation, lung destruction, and increased mortality. Therefore, CF patients should be ...
متن کاملAntibiotic Susceptibility of Pseudomonas Aeruginosa Isolated from Cystic Fibrosis Patients
Abstract Background and Objective: Cystic fibrosis (CF) is an autosomal recessive genetic disease and Pseudomonas aeruginosa is one of the most common bacteria colonized in CF patients. Growing resistance of this bacterium to antibiotics now a day is a challenge of controlling infection in CF patient. In this study colonization of CF patients with Pseudomonas aeruginosa and antibiotic suscep...
متن کاملIn vitro assessment of combined antibiotic and mucolytic treatment for Pseudomonas aeruginosa infection in cystic fibrosis.
The minimal inhibitory concentration of azlocillin for Pseudomonas aeruginosa is appreciably reduced when combined with the mucolytic agent mesna (Mistabron) because of an independent bacteriostatic effect of mesna. Bactericidal activity of azlocillin is unaltered by mesna. Mesna inhalations alone or combined with azlocillin may benefit cystic fibrosis patients with pseudomonas lung infections.
متن کاملRecent advances in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis
Chronic Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) patients is caused by biofilm-growing mucoid strains. Biofilms can be prevented by early aggressive antibiotic prophylaxis or therapy, and they can be treated by chronic suppressive therapy. New results from one small trial suggest that addition of oral ciprofloxacin to inhaled tobramycin may reduce lung inflammation. Clinica...
متن کامل